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KMID : 0644120080210020027
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Journal of Oriental Gynecology
2008 Volume.21 No. 2 p.27 ~ p.37
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Effects of Ginseng Radix Alba on Cell Cycle and Apoptosis of Human Uterine Myoma Cells
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Choi Jae-Ho
Lee Jin-Moo
Lee Chang-Hoon
Cho Jung-Hoon
Lee Kyung-Sub
Jang Jun-Bock
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Abstract
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Purpose: This study was conducted to investigate the effects of Ginseng Radix Alba extract solution on the cell cycle regulation, apoptosis of human uterine myoma cells.
Methods: Primary cultured human uterine myoma cells were treated with extract solution of Ginseng Radix Alba concentration of 1, 10 and 100㎎/㎖ for 48 hours. We underwent flow cytometry and western blotting for cell cycle and
apoptosis related factors.
Results: In flow cytometry, a slight promotion of G1 phase in 1㎎/㎖ group had been observed but, imultaneously a delay of G1 phase in 10 and 100㎎/㎖ groups were also observed. The manifestation of cyclin D1 in Ginseng Radix
Alba extract solution medicated group increased compared to the control group. The manifestation of Bax controlling apoptosis increased in terms of concentration but Bcl-2 showed no change. Also VEGF increased in terms of concentration.
Conclusion: The present study suggests that Ginseng Radix Alba extract solution treatment in human uterine myoma cells induce the delay of cell cycle and apoptosis. These results suggest that Ginseng Radix Alba will be a promising agent for use in therapeutics agents against human uterine myoma.
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KEYWORD
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Ginseng Radix Alba, Uterine myoma, Cell cycle, Apoptosis
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